FHL1 and age-related macular degeneration: While these findings point to a special role of FHL-1 in the context of ocular complement regulation, also variants outside of FHL-1, like the c.3628C>T (p.Arg1210Cys) variant, were shown to be associated with increased AMD risk (5,10), indicating that reduced availability of full-length FH is also a risk factor for AMD.