In AMD patients, a burden of rare coding variants in the CCP domains one to four has been identified (19), and while FHL-1 is with 10–50 μg/ml less abundant than full-length FH in plasma (23), equal concentrations of FHL-1 and FH have been identified in aqueous humor likely due to higher permeability of Bruch’s membrane for FHL-1 (7,24). The gene discussed is FHL1; the disease is age-related macular degeneration.