IL2RA and autoimmune disease: Simeonov et al. applied CRISPRa screening to interrogate autoimmune disease susceptibility loci associated with CD69 and IL2RA. Tiling CRISPR/dCas9-VP64 in Jurkats over the risk region and sorting cells based on expression of either CD69 or IL2RA led to the identification of potential regulatory elements which they referred to as CRISPRa-responsive elements (CaRE).