Meanwhile, KIF5B-RET15, CCDC6-RET16, EZR-ROS117, PHF20-NTRK118, and TRIM24-BRAF19 have been reported to function as resistance mechanisms to EGFR 19del upon EGFR TKIs treatment in NSCLC patients. This evidence concerns the gene EGFR and non-small cell lung carcinoma.