In summary, we clarified one of the mechanisms of the migration and invasion of AB cells in the tumor progression revealing that TGF-β stimulation activated TAK1 by inducing its phosphorylation, then, αTAT1 was activated by interacting with p-TAK1 causing tubulin acetylation, which finally contributed to the migration and invasion of AB cells. Here, ATAT1 is linked to neoplasm.