In order to decipher the genome-wide landscape of the network of protein coding and long-non coding genes mediating interferon antiviral activity in hepatoma cell lines, we profiled by RNAseq the transcriptome of Huh7 and Huh7.5 cells treated with interferon alpha (IFNα), beta (IFNβ) or lambda (IFNλ) for 8 h. Here, IFNB1 is linked to hepatocellular carcinoma.