Recently, several signature genes have been associated with poor prognosis in CML, including IGFBP2, SRSF11, BAX, CDKN1B, BNIP3L, FZD7, PRSS57, and MRPS2845,46. The gene discussed is BNIP3L; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.