Although two key DC development-related genes, IRF8 and FLT3, were found to be strongly suppressed in CML cells, in vitro retroviral transduction experiments using mouse HSPCs suggested that IRF8 is particularly critical because exogenous expression of IRF8, but not FLT3, restored cDC differentiation. Here, IRF8 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.