In this study, we analyzed BM progenitor cells in newly diagnosed CML patients and revealed that cDC differentiation is perturbed from an early progenitor stage of myelopoiesis due to downregulated interferon regulatory factor-8 (IRF8), a transcription factor essential for the development of cDC1s19,23. The gene discussed is IRF8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.