We speculate that this may involve an epigenetic mechanism, which accompanies memory, for several reasons: (1) IRF8 epigenetically primes cDC-related genes in mouse LMPPs49, (2) IRF8 expression is reduced in HSPCs of a mouse CML model22 and CML patients (this study), and (3) neighboring BCR-ABL+ progenitors memorize the influence from BCR-ABL+ cells to cause a myeloid bias in CML50. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.