ADHFE1 and metabolic dysfunction-associated steatotic liver disease: We also compared our candidate signatures with two other published NAFLD fibrosis signatures: Only a single gene, ADHFE1, overlaps with the 18-gene fibrosis signature reported by7, while three genes overlap with the 25-genes progression signature derived by10 i.e. IL32, STMN2, and DTNA. Between the two published gene signatures there is one overlapping gene, TNFRSF12A. Interestingly, IL32 has been previously reported as the top up-regulated liver transcript in NAFLD39.