CDKN1C is an inhibitor of several G1 cyclin/CDK complexes which is involved in the regulation of several hallmarks of cancer, including cell proliferation, apoptosis, cell invasion and metastasis, tumor differentiation, and angiogenesis27, whereas FRY plays a role in centrosome integrity maintenance during mitosis and could interact with AURKA to mediate PLK1 activation28. This evidence concerns the gene PLK1 and cancer.