Second, Gene Set Enrichment Analysis (GSEA) was carried out ordering all the studied genes by their correlation value with PER3. GSEA analysis results of the D1 dataset showed that PER3 positively correlated genes were enriched in several biological processes besides circadian clock machinery (Fig. 3b) including pathways relevant for cancer such as, PI3K/AKT, insulin, and PPAR signaling, the synthesis of ATP thought the electron transport chain, the metabolism of fatty acids. This evidence concerns the gene AKT1 and cancer.