VIM and carcinosarcoma: Consistent with high EMT association with MpBC, we saw that differential expression of EMT markers, for example, up-regulated Vim and Lgals1 and down-regulated Cdh1, was greater in metaplastic carcinosarcomas compared to carcinomas, consistent with protein levels of E-cadherin and vimentin, identified via IHC in TRIM24-driven tumors (Fig. 2b).