This cutting-edge report revealed that MpBC patient samples, as well as spindle MpBC-like tumors that develop in a mammary epithelial-specific Ccn6 knockout mouse48, have enrichment in EMT and E2F pathways at protein levels consistent with our transcriptomic analysis of both MpBC TRIM24 signature and TRIM24-driven metaplastic carcinosarcoma tumors. The gene discussed is CCN6; the disease is carcinosarcoma.