We next explored specific examples of genes with high MD-AD rankings and strong interactions with sex (i.e., the six genes from the top 100 MD-AD list with the strongest interaction p values; Fig. 5c, d): KNSTRN, C4B, CMTM4, TREM2, P2RY11, and SERPINA3. For each of these genes, we observed high expression values associated with higher neuropathology predictions but some stratification across sexes: high expression in females led to especially high neuropathology predictions for KNSTRN and P2RY11, while the opposite was true for the other four genes. Here, KNSTRN is linked to Alzheimer disease.