TREM2 and Alzheimer disease: We next explored specific examples of genes with high MD-AD rankings and strong interactions with sex (i.e., the six genes from the top 100 MD-AD list with the strongest interaction p values; Fig. 5c, d): KNSTRN, C4B, CMTM4, TREM2, P2RY11, and SERPINA3. For each of these genes, we observed high expression values associated with higher neuropathology predictions but some stratification across sexes: high expression in females led to especially high neuropathology predictions for KNSTRN and P2RY11, while the opposite was true for the other four genes.