The canonical proinflammatory molecules associated with SnC accumulation and their SASP in osteoarthritis are cytokines (IL-1β, IL-6, TNFα), chemokines (CCL2, CCL4), proteases (MMPs, ADAMTS), and growth factors (TGFβ, IGFBP).109 The identification of the SnCs in the osteoarthritic joints and their contribution to the disease development have also been discussed in recent comprehensive review articles.109,121. This evidence concerns the gene IL1B and osteoarthritis.