SIRT1 and osteoarthritis: Furthermore, sirtuin-1 (SIRT1) is a crucial enzyme to ECM homeostasis and chondrocyte survival,147 and SIRT1 cleavage has been correlated with chondrosenescence and osteoarthritis.148 In another study, ACLT in mice induced SIRT1 cleavage, and systemic navitoclax delivery combined with intra-articular UBX0101 delivery decreased the amount of circulating cleaved SIRT1.148 Another senolytic that is currently being assessed in clinical trials is fisetin (NCT04210986).