Of MMPs, the most highly expressed is MMP13, which can efficiently degrade type-II collagen in articular cartilage.151 Patients with osteoarthritis express higher levels of MMP13 in their chondrocytes than do healthy patients,152 and MMP13 has been identified as a primary driver of osteoarthritis.153 CL82198, an MMP13 inhibitor, decreased osteoarthritis-related degeneration and pain, decreased chondrocyte cell death, and increased type-II collagen levels.154 Therefore, MMP13 inhibitors could be a promising therapy for osteoarthritis patients. Here, MMP13 is linked to osteoarthritis.