Consistently, Kaplan–Meier plotter showed that higher expression of TRIM3 correlated positively with poorer overall survival (OS), relapse-free survival (RFS), and distant metastasis-free survival (DMFS) in cases of ER+ breast cancer with tamoxifen treatment and/or chemotherapy, but not in ER− breast cancer (Figs. 1C and S1C). This evidence concerns the gene ESR1 and breast cancer.