In agreement with these consequences, we concluded that FZD4 was highly expressed in OC tissues and cells, and FZD4 overexpression reversed the anti-tumor effects of miR-331-3p, hinting that FZD4 was an oncogene in OC, which was consistent with the carcinogenic properties of FZD4 in other cancers [30–32]. This evidence concerns the gene FZD4 and neoplasm.