NECTIN2 and hepatocellular carcinoma: A recent study showed that CD112 was overexpressed in HCCs compared with that of adjacent tissues based on RNA sequencing (RNA-seq), single cell RNA-seq (scRNA-seq) and IHC, and HCC tumors were significantly smaller through recovering T cell infiltration, and tempering T cell exhaustion in Nectin-2 (CD112) KO mouse HCC model [44].