NECTIN2 and cancer: The authors found that serum concentrations of CD112 (5.0 ng/mL vs. 0.650 ng/mL; p < 0.0001) and nectin-4 (2.45 ng/mL vs. 1.15 ng/mL; p < 0.001) were significantly up-regulated in the cancer patients compared to those in the controls.