Downregulation of the m6A writers METTL3 and WTAP in aortic tissue during sepsis is thus consistent with both LC-MS data, which suggested a decrease in global m6A demethylase activity for the mRNA pool, and with microarray results, which showed decreased m6A levels in 84.8% of the mRNA/lncRNA transcripts with significantly altered m6A status. This evidence concerns the gene METTL3 and Sepsis.