AKT1 and pancreatic neoplasm: The anti-angiogenic effects of CORM-2 have also been documented in a few other cancer models, such as in gastric cancer by mitigating IL-1β-induced IL-8 expression which is crucial for endothelial cell proliferation and angiogenesis [67], or in pancreatic cancer by inhibiting Akt phosphorylation which is important for cancer neovascularization [68].