In addition, the miR-15/16 cluster has been shown to be deleted or its expression down-regulated in two-thirds of B cell chronic lymphocytic leukemia (B-CLL) cases, which is characterized by the clonal expansion of CD5+ B cells and is similar to that seen in EBL [2, 140, 141]. This evidence concerns the gene CD5 and B-cell chronic lymphocytic leukemia.