Among the pathways with gene alterations were the Receptor tyrosine kinase–Ras pathway (altered in 75% of all tumours; S1 Fig), Wnt pathway (altered in 29% of all tumours; Fig 5A), the PI3K-mTOR pathway (23%; Fig 5B) and Transforming Growth Factor Beta Signalling Pathway (48%; Fig 5C). Here, MTOR is linked to neoplasm.