Coronavirus has been known to affect neuronal tissue by various mechanisms such as direct injury via neuronal pathways being transported through neuronal proteins such as dynein and kinesin, hypoxic injury, immune injury, and binding to ACE-2.13 Netland et al. have a well-documented spread of viral antigen intracranially via olfactory bulb in K18-hACE2 mice model.14 While the lungs are the major site of infection, the brain is also infected in some patients. The gene discussed is ACE2; the disease is infection.