THBD and Sepsis: Prior data published from our group and others have demonstrated that markers of endothelial activation/dysfunction, such as Angpt-2 (23, 50), VEGFR-1 (50), E selectin (50), P selectin (51), thrombomodulin (52), vWF (53), and D-dimer (52), are elevated in sepsis, scale with disease severity, and in some cases may be predictive of survival.