CD4 and obesity due to melanocortin 4 receptor deficiency: DEIRGs were primarily enriched in chemokine signalling pathway, G-protein coupled receptor signalling pathway, JAK-STAT signalling pathway, natural killer cell mediated cytotoxicity, and Fc epsilon RI signalling pathway, etc. Confirming with previous evidence, obesity caused a low degree of chronic inflammation characterized by infiltration of B-cells, neutrophils, natural killer T cells, Th1 CD4 + T cells, macrophages, and CD8 + T cells into adipose tissue [29].