To fully investigate the function of the lncRNA NBR2 in the development and progression of CRC cells, the lncRNA NBR2 overexpressed macrophages and the lncRNA NBR2 knockdown macrophages were established by transfecting macrophages with pcDNA3.1-NBR2 and siRNA against the lncRNA NBR2, respectively. The gene discussed is NBR2; the disease is colorectal carcinoma.