The migration rate of HCT116 and SW480 cells was decreased greatly by co-incubating with M0 macrophages transfected with pcDNA-NBR2 and promoted by the co-incubation of M0 macrophages transfected with si-NBR2, compared with M0 macrophages (*P < 0.05, vs. M0; **P < 0.01, vs. M0), indicating an inhibitory effect on the metastasis of CRC cells by NBR2-overexpressed macrophages. The gene discussed is NBR2; the disease is colorectal carcinoma.