Significantly higher expression levels of the M2 microphage markers Arg-1, CD163, and CD206 were observed in tumor tissues than in para-carcinoma tissues, as well as the upregulated IL-4 in tumor tissues, which is an inducer of polarization from M2 macrophages to M1 macrophages (**P < 0.01, vs. Control). The gene discussed is CD163; the disease is carcinoma.