This decrease in circulating T, especially in obese diabetic individuals, is related to lower sex hormone‐binding globulin SHBG) levels resulting from decreased hepatic synthesis of this protein.20 It is thus hypothesized that steroidal biosynthesis in leydig cells are impaired in the presence of visceral obesity and IR, features seen in T2DM.16, 21. Here, SHBG is linked to type 2 diabetes mellitus.