PLOD1 and Hypergonadotropic hypogonadism: It has been observed that low circulating T leads to lack of negative feedback inhibition on LH and FSH secretion, leading to primary hypogonadism.13, 16, 32, 33 Further to this, kisspeptin has been suggested to have the ability to increase LH pulsatility and T concentrations in T2DM males with reproductive disorders such as hypogonadism.14, 28 Dhillo and friends,27 initially reported that the administration of exogenous kisspeptin stimulated the hypothalamic‐pituitary‐gonadal axis in human males causing a rise in LH, FSH and T concentrations.