Thus, under normal physiology, kisspeptin excites the hypothalamic GnRH neurocytes to produce GnRH into circulation, subsequently stimulating the production of gonadotrophs LH, FSH), which stimulates sex organs in humans to produce T and sperms.27, 34 Indeed, a novel treatment of kisspeptin administration has been demonstrated to treat infertility in these males with T2DM.35 These evidences point to a strong direct influence of kisspeptin in the hypothalamic‐pituitary‐gonadal axis, where adequate levels of circulating kisspeptin are needed to regulate the gonadal‐pituitary axis. Here, GNRH1 is linked to Infertility.