This is supported by a WHO report stating that about 90% of individuals that develop T2DM have excess body weight.10 Consistent with the American Diabetes Association, impaired glucose control, as evidenced in T2DM, tends to increase blood concentrations of sugar, which increases the exposure of glucose to certain proteins leading to increased formation of glycated derivatives.36 The direct impact of kisspeptin on metabolism has only recently been recognized with kisspeptin implicated in regulating glucose homoeostasis. This evidence concerns the gene KISS1 and type 2 diabetes mellitus.