Related studies targeting middle‐aged men showed that about 25%‐40% of T2DM men have reduced T concentration, resulting in diabetes‐related dysfunction 16, 18 and abnormal functioning of cells in the hypothalamus that secretes luteinizing hormone‐releasing hormone LHRH).2, 19 This suggests insulin resistance as well as hyperglycaemia could also play a role in the pathogenesis of hypogonadism. This evidence concerns the gene GNRH1 and hypogonadism.