Biologically, active kisspeptin excites the neurons associated in gonadotrophin‐releasing hormone GnRH) production.2, 3, 4 Loss‐of‐function or genetic changes in the signalling pathway of kisspeptin have resulted in congenital hypogonadotropic hypogonadism CHH) and impaired sexual development.5 Kisspeptin receptor knockout mice showed hypogonadotropic hypogonadism HH; however, administration of endogenous GnRH corrected the levels of GnRH suggesting the involvement of kisspeptin in stimulating endogenous GnRH 6, 7 and decisively influencing the pituitary‐gonadal axis. The gene discussed is GNRH1; the disease is cartilage-hair hypoplasia.