For those outcomes that co-localised only at one genomic locus, there was evidence for association between genetically proxied GIP signalling and lower risk of coronary artery disease (OR [95% CI] = 0.51 [0.37, 0.71]), lower alanine aminotransferase (−0.13 [−0.20, −0.07]) and lower systolic BP (−0.18 [−0.25, −0.12]) at the GIP locus, with all these the estimates exceeding those obtained for reduced type 2 diabetes liability more generally (ESM Fig. 4; ESM Table 7). Here, GPT is linked to coronary artery disorder.