For depression, one study did not find evidence for a potential causal role of inflammation [25], while more recent studies reported potential causal roles for increased IL-6 and CRP serum concentrations in depression [26], for increased IL-6 activity for suicidality specifically [27], and for increased soluble IL-6R levels for recurrent depressive symptoms [28]. The gene discussed is IL6R; the disease is depressive symptom measurement.