The development of abdominal aortic aneurysm (AAA) is characterized by VEGF-induced angiogenesis through cyclooxygenase-2 (COX-2), while quercetin can inhibit COX-2 and reduce HIF-1α/VEGF signaling-related angiogenesis, thereby inhibiting aneurysm growth (44). The gene discussed is VEGFA; the disease is abdominal aortic aneurysm.