LCZ696, a new combination of angiotensin and enkephalinase inhibitor, could reduce the protein expression levels of VEGF-C, VEGFR3, and LYVE-1 in heart tissue of mice and improve the transport load of lymphatic vessels to macrophages, thus inhibiting the remodeling of lymphatic system in a hypertrophic cardiomyopathy model (112). Here, FLT4 is linked to hypertrophic cardiomyopathy.