The decreased LDL-C in COVID-19 patients may be due to the following reasons: (1) decreased plasma LDL levels were caused partially by tumor necrosis factor (TNFα) (7); (2) upregulation of interleukin 6 (IL-6) decreased LDL-C levels by stimulating the uptake of LDL particles (23). This evidence concerns the gene IL6 and COVID-19.