An example of this is obtained by observing the high levels of ceruloplasmin found in various forms of cancer, such as lymphomas, breast cancer, and gastrointestinal cancer (Scanni et al., 1977; Ungar-Waron et al., 1978; Linder and Roboz 1986; Gupte and Mumper 2009), and ceruloplasmin levels have been found to be increased 4 to 8 times during malignant progression, returning to normal levels after tumor regression (Brem et al., 1990; Brem 1999). The gene discussed is CP; the disease is breast carcinoma.