SMPDL3B and acute myeloid leukemia: To further confirm whether SMPDL3B knockout had suppressive effects on AML tumor growth in vivo, the Kasumi-1 cells with wild type SMPDL3B (SMDPL3B-WT) or knockout SMPDL3B (SMPDL3B-KO) were subcutaneously injected into nude mice for xenograft.