ACHE and perinatal asphyxia: Researchers found that MCPS promoted long-term learning and memory in perinatal asphyxia (PA) pups by decreasing oxidative damage and acetylcholinesterase (AChE) activity in the brain, and increasing the expression of p-CREB and brain-derived neurotrophic factor (BDNF) in the hippocampus (53).