STAT3 and Hepatic fibrosis: We showed that similar to mouse models of skin, lung, and liver fibrosis (Pedroza et al., 2016; Kasembeli et al., 2018; Pedroza et al., 2018), inhibition of STAT3 signaling with the small molecule TTI-101 significantly reduced T. cruzi-induced pSTAT3 levels and tissue fibrosis.