STAT3 and fibrosis: Given previous evidence that signaling pathways involving STAT3 are altered in chronic fibrotic diseases and evidence showing altered STAT3 signaling in T. cruzi infected cells in vitro, we conducted the studies described here to determine the in vivo effect of inhibiting STAT3 on cardiac fibrosis development in CCC (Ponce et al., 2013; Kasembeli et al., 2018).