Previous findings have shown that multiple polymorphisms in the promoter region (−574G/T, −882C/T, −1516G/T, and −1541C/T) and in the coding region (+4259T/G, amino acid substitution: Arg to Leu) of the Tim-3 gene were associated with several types of malignant tumors such as non-small-cell lung cancer (23), pancreatic cancer (24), and gastric cancer (25). The gene discussed is HAVCR2; the disease is cancer.