One of the reasons why RM2 was associated with better prognosis was because RM2 was associated with higher expressions of HLA-A and higher numbers of tumor-infiltrating CD8+ T cells, helper T cells, and activated NK cells but lower expressions of Tim-3, PD-L1, PD-L2, and CC chemokine receptor 4 (CCR4). This evidence concerns the gene CD8A and neoplasm.