IFNG and neoplasm: The results show that Tim-3 blockade enhances anti-tumor immunity by upregulating genes through means such as acetylation, cell differentiation, apoptosis, TGF-β signaling, immune response, negative regulation of angiogenesis, activation of the IFN-γ-mediated pathway, and mitogen-activated protein kinase signaling that favor immune cell proliferation and activation and enhance T-cell cytotoxicity (80).