Twenty-four of the 53 (45.2%) patients received subsequent anti-tumor therapies, including chemotherapy (12/53, 22.6%), immune checkpoint inhibitors (14/53, 26.4%), angiogenesis inhibitors (14/53, 26.4%), BRAF with or without MEK inhibitor re-challenge (8/53, 15.1%), and radiation therapy (2/53, 3.8%) (Table S3 in the Supplementary Appendix). The gene discussed is BRAF; the disease is neoplasm.