This suggested that the poor prognosis of the low-PCSK9-Ab group but not of the high-PD-L1 group can be explained by hypercholesterolemia or diabetes mellitus because hyperlipidemia and diabetes mellitus have been reported to be relevant and independent risk factors for the recurrence of esophageal cancer (48). The gene discussed is PCSK9; the disease is Hypercholesterolemia.