Both EGR2 and MEF2B are regulators of cell transcription (130, 131), and the former was reported to be involved in the epithelial-mesenchymal transition (EMT) pathway (131, 132), while the latter was differentially expressed between primary tumors and nodal metastasis tumor in HNSCC (53). The gene discussed is EGR2; the disease is head and neck squamous cell carcinoma.