For instance, CSTB seems to be upregulated in HCC (25–28), epithelial ovarian tumors (29, 30), and breast cancer (31), but downregulated in ESCC (32, 59) and laryngeal squamous cell carcinoma (33) (another certain kind of HNSCC). The gene discussed is CSTB; the disease is laryngeal squamous cell carcinoma.