CXCR4 and neoplasm: The expression of genes encoding factors involved in the suppression of immune responses, i.e.: ApoE – a marker of an anti-inflammatory GAMs phenotype (49), CD69 – a negative regulator of immune responses implicated in inducing the exhaustion of tumor-infiltrating T cells (50), and Cxcr4 – a receptor for the immunosuppressive chemokine Cxcl12, were downregulated in the OAT-1746 and COMB groups.