In comparison with healthy control subjects, no difference was found in patients with CRSsNP for all these MMPs and TIMPs, while increased levels of MMP‐3, MMP‐7, MMP‐8, MMP‐9 and TIMP‐1, and TIMP‐2 were found in patients with CRSwNP. This evidence concerns the gene TIMP2 and chronic rhinosinusitis with nasal polyps.