When the analysis was adjusted for CRSsNP, the odds ratios (OR) were 1.391, 1.015, 1.005, 1.006, 1.006, 1.013, and 1.029 for MMP‐3, MMP‐7, MMP‐8, MMP‐9, TIMP‐2, periostin, and tenascin C, respectively (p < 0.05). This evidence concerns the gene POSTN and chronic rhinosinusitis without nasal polyps.