When the analysis was adjusted for CRSsNP, the odds ratios (OR) were 1.391, 1.015, 1.005, 1.006, 1.006, 1.013, and 1.029 for MMP‐3, MMP‐7, MMP‐8, MMP‐9, TIMP‐2, periostin, and tenascin C, respectively (p < 0.05). The gene discussed is MMP9; the disease is chronic rhinosinusitis without nasal polyps.