When the analysis was adjusted for CRSsNP, the odds ratios (OR) were 1.391, 1.015, 1.005, 1.006, 1.006, 1.013, and 1.029 for MMP‐3, MMP‐7, MMP‐8, MMP‐9, TIMP‐2, periostin, and tenascin C, respectively (p < 0.05). Here, TNC is linked to chronic rhinosinusitis without nasal polyps.