Regarding the correlations of ECM proteins with the expression of MMPs and TIMPs, and the fact that fibroblasts are the main source of MMPs and TIMPs, we first observed the regulation by ECM proteins of MMP‐3, MMP‐7, MMP‐8, MMP‐9 and TIMP‐1, and TIMP‐2 gene expression in nasal polyp‐derived fibroblasts. The gene discussed is MMP3; the disease is Nasal polyposis.