Thus a pan-anti allergy vaccine can be computationally designed by excising the motif (a motif on or near the IgE antibody’s receptor binding site) of interest from the IgE structure and grafting it onto a scaffold protein structure, thus displaying only the motif of interest in its original three-dimensional form without any of the surrounding native structure, allowing the immune system to target just that particular motif. Here, IGHE is linked to allergic disease.