IGHE and parasitic infectious disease: Immunoglobulin E (IgE) on the other hand, is thought to be concerned with extracellular parasitic infections, where an association was found between Schistosoma mansoni infections and higher levels of serum IgE [4], as well as noxious toxin immunity (such as venom) [5] where it seems the immune system attacks forgein enzymes such as Apis mellifera (bee) phospholipase A2 (Api m 1), Dermatophagoides pteronyssinus (mite) peptidase (Der p 1), and Persea americana and (avocado) endochitinase (Pers a 1).