Dual inhibition of MAP2K7 and TAK1 could be beneficial in T-ALL because TAK1 may act as MAP3K upstream of MAP2K7; however, lack of inhibition of MAP2K7 phosphorylation in most T-ALL cell lines suggested that 5Z7O cytotoxicity was mediated mainly through MAP2K7 inhibition. The gene discussed is MAP2K7; the disease is acute lymphoblastic leukemia.