Treatment with daunorubicin for 36 hours induced chromosome breaks in Ba/F3-ITD and 32D-ITD cells, both transfected with human FLT3-ITD, as well as in the human FLT3-ITD AML cell lines MV4-11 (homozygous FLT3-ITD) and MOLM-14 (heterozygous FLT3-ITD), and numbers of chromosome breaks were decreased with concurrent treatment with AZD1208 (Figure 6A). This evidence concerns the gene FLT3 and acute myeloid leukemia.