Additionally, succinate, a tricarboxylic acid (TCA) cycle intermediate which could serve as an activation signal in macrophages stimulated by lipopolysaccharide (LPS) [39], was overproduced from adipose tissue in mice under stressed conditions like hypoxia and hyperglycemia and induced upregulated chemotaxis in ATM towards CLS through activation of succinate receptor 1 (SUCNR1) [40]. This evidence concerns the gene SUCNR1 and Hyperglycemia.