ERCC1-xeroderma pigmentosum (XP) F is a structure-specific protein complex which acts as an endonuclease enzyme involved in the repair of several types of DNA lesions, mainly bulky, helix-distorting lesions that are repaired by the nucleotide excision repair pathway, but also double-strand breaks and interstrand cross-links [10–12]. Here, ERCC1 is linked to xeroderma pigmentosum.