Furthermore, in animal models of PWS, knockout Snord116 mice displayed cognitive deficits (Adhikari et al., 2019), growth retardation (Ding et al., 2008), hyperphagia, and marked obesity (Polex-Wolf et al., 2018; Yang et al., 2019). Here, SNORD116 is linked to obesity due to melanocortin 4 receptor deficiency.