The deletion in patient 288417 of DECIPHER database, detected as 516 kb in size, encompassed five OMIM genes: NPAP1, PWRN1, SNHG14, SNORD116, and SNRPN. Also, patient 288417 showed a core phenotype characterized by obesity, aggressive behavior, intellectual disability, and psychosis (information of infant period was not provided), pointing toward a causative role of the genes in the minimal critical region in the broader phenotype of typical PWS. This evidence concerns the gene NPAP1 and obesity due to melanocortin 4 receptor deficiency.