TNF and colorectal carcinoma: We observed that multifunctional, memory TILs target many of the phosphopeptides identified in a CRC liver metastasis sample (CRCLM1) and a single phosphopeptide in primary CRC sample - CRC3 (RRIsDPQVF, which was predicted to bind HLA-C*06 in this patient), producing TNFα, IFNγ, and IL-2, but no TIL responses targeting phosphopeptides were detected in CRCLM2 (Figures 3C–E and Supplementary Figures 6–8).