Thus, in SLE patients, the expansion of B cells lacking IgD and CD27 [double negative (DN)] reflects a subset of CXCR5−CD11c+T-bet+ cells (DN2), which represent the precursors of autoantibody-producing plasma cells, also termed by others as antibody-secreting cells (ASCs) (64, 65). The gene discussed is CD27; the disease is systemic lupus erythematosus.