By these means, elevated expression of several proinflammatory cytokines including IL-6, IL-1β, MCP-1, IP-10, TNF, granulocyte colony-stimulating factor (G-CSF), and a weakened type I interferon (IFN-I) responses were reported in the peripheral blood of severe COVID-19 patients (21–23, 26). This evidence concerns the gene CSF3 and COVID-19.