IL6 and cardiac hypertrophy: Up-regulated IL-6 promotes cardiac hypertrophy by aggravating mitochondrial dysfunction caused by oxidative stress through gp130/STAT3 signaling pathway, and induces excessive ROS production by regulating mitophagy level and increasing mitophagy-related protein expression, consequently exaggerating cardiomyocyte apoptosis (Huo et al., 2021).