During myocardial ischemia-reperfusion, cardiomyocytes release IL-6, which induces neutrophils and cardiomyocytes to express CD11b/CD18 and intercellular adhesion molecule-1 (ICAM-1), thereby damaging the myocardium (Gwechenberger et al., 1999). The gene discussed is IL6; the disease is myocardial ischemia.