Some studies have found that cytokines such as TNF-α, IL-1α/β and IL-6 affect phospholipid metabolism during acute inflammatory reaction under cerebral ischemia, producing arachidonic acid-like substances, ceramides and reactive oxygen species (ROS), which can cause damage to the brain tissue (Adibhatla et al., 2008). The gene discussed is TNF; the disease is Cerebral ischemia.