IL6 and hydrops fetalis: In HF, a variety of cells produce inflammatory mediators like IL-6, which is not only a sign of inflammatory activation, but also may induce systolic dysfunction, ventricular dilatation, cardiomyocyte hypertrophy and apoptosis through different mechanisms, directly acting on the pathological process of HF (Yndestad et al., 2006), promoting the progress and deterioration of HF.