The activation of PPAR-α, PPAR-δ, and Scd1 has been shown to play a role in DSS-colitis, and Hmgcs2 has an effect in TNBS-colitis (Bassaganya-Riera et al., 2004; Wang et al., 2016b; Wang et al., 2017; Liu et al., 2018). Here, HMGCS2 is linked to colitis.