We found that salidroside significantly improved IH-induced endothelial barrier injury in both ApoE-/- mice and HUVECs, suggesting that salidroside may alleviate CIH-aggravated atherosclerosis by improving endothelial barrier damage, and endothelial barrier dysfunction may be a mechanism by which IH aggravates atherosclerosis. Here, APOE is linked to atherosclerosis.