APOE and cardiovascular disorder: In addition, CIH promoted atherosclerotic plaque formation in both normal and high cholesterol diet-fed ApoE-/- mice (Drager et al., 2013; Gautier-Veyret et al., 2013; Gileles-Hillel et al., 2014) However, CPAP cannot improve the incidence or mortality rate of cardiovascular diseases in OSA patients, and compliance with CPAP treatment was shown to be very low in actual practice (McEvoy et al., 2016; Peker et al., 2016).