SHANK3 and Alzheimer disease: To quantitatively assess the effect of age and AD-like pathology on Shank3 expression, densitometric analyses were carried out in selected neocortical, hippocampal, and cerebellar areas, using the Motic images of immunolabeled sections from the prefrontal lobe, the parietal and temporal lobes at the mid-hippocampal level, and posterior lobe of the cerebellum (Figures 13A–D).