Multiple forms of SHANK3 mutation are also found in individuals with Phelan-McDermid Syndrome Contribution of SHANK3 mutations to autism spectrum disorder (Watt et al., 1985; Bonaglia et al., 2006, 2011; Toro et al., 2010; Phelan and McDermid, 2012; Zwanenburg et al., 2016), schizophrenia (Failla et al., 2007; Gauthier et al., 2010; de Sena Cortabitarte et al., 2017), and bipolar disorder (Denayer et al., 2012; Vucurovic et al., 2012; Crisafulli et al., 2013; Ortiz et al., 2015). The gene discussed is SHANK3; the disease is bipolar disorder.